The series focuses on Brian Finch, who discovers the power of a mysterious drug called NZT-48 which increases his IQ to four digits and gives him perfect recall of everything he has ever read, heard, or seen. Fueled now with a steady supply of NZT that enables him to use 100% of his brain capacity, Brian is more effective than all of the FBI agents combined, making him a criminal's worst nightmare and the greatest asset the Bureau has ever possessed.